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Article: Local connections of excitatory neurons to corticothalamic neurons in the rat barrel cortex.

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Tanaka YR; Tanaka YH; Konno M; Fujiyama F; Sonomura T; Okamoto-Furuta K; Kameda H; Hioki H; Furuta T; Nakamura KC; Kaneko T
J. Neurosci., 2011


Table 3.

Electrophysiological properties of sampled cortical pyramidal neurons

Pyramidal neuron group
L2/3 (n = 5) L4 (n = 5) L5a (n = 3) L5b (n = 5) L6+ (n = 5) L6− (n = 5)
Resting membrane potential (mV) −73.0 ± 2.6 −68.0 ± 7.4 −61.5 ± 7.6 −64.8 ± 8.7 −68.4 ± 3.7 −66.2 ± 7.0
Membrane time constant (ms) 11.5 ± 2.6 7.5 ± 4.5 11.5 ± 4.6 11.7 ± 5.1 9.8 ± 3.0 7.9 ± 2.6
Input resistance (MΩ) 51.1 ± 27.5 68.3 ± 28.8 65.3 ± 34.4 48.7 ± 29.5 62.2 ± 18.1 48.1 ± 11.8
Action potential (AP) threshold (mV) −47.6 ± 7.9 −41.3 ± 15.6 −40.2 ± 7.2 −50.6 ± 10.5 −41.4 ± 5.1 −43.1 ± 7.1
AP height (mV)a 96.2 ± 8.0 103.8 ± 10.2 85.9 ± 10.0 97.9 ± 5.7 89.4 ± 6.4 94.0 ± 16.8
AP half width (ms) 0.85 ± 0.24 0.86 ± 0.39 0.88 ± 0.18 0.72 ± 0.29 0.77 ± 0.16 0.71 ± 0.13
Fast afterpotential (mV)b 2.7 ± 2.8*,‡‡‡ −1.5 ± 2.0††,‡ −3.9 ± 3.0††† 4.9 ± 2.6‡‡‡ −6.1 ± 3.3††† −1.1 ± 3.0†,‡
Slow afterpotential (mV)b −1.2 ± 1.3 −1.6 ± 1.0 −4.9 ± 0.7 −2.5 ± 4.4 −2.4 ± 3.3 −3.3 ± 1.9

  • ↵*,†,‡Significant differences (*,†,‡p < 0.05;††p < 0.01;†††,‡‡‡p < 0.001 by Peritz's F test) from the value of L5a, L5b, or L6+ neurons, respectively.

  • ↵aAP height was measured from resting membrane potential.

  • ↵bFast and slow afterpotential was measured from baseline prior to action potential evoked by a short (< 5 ms) depolarizing pulse, at 3.3 ms or 29 ms from action potential onset, respectively. Pulse response without action potential to the same depolarizing pulse was recorded in another trace and subtracted. Our previous study showed that one type of L6 pyramidal neurons has a peak of fast afterhyperpolarization (AHP) at 3.3 ms on average, and that another type of L6 pyramidal neurons lacks fast AHP and has a peak of medium-range AHP at 29 ms on average (Kaneko et al., 1995).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 barrel cortex pyramidal neurons layer 2/3 resting membrane potential (mV) -73.0 ± 2.6 (5) -73.0 (mV) Data Table
Neocortex layer 4 stellate cell barrel cortex layer 4 neurons resting membrane potential (mV) -68.0 ± 7.4 (5) -68.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5a resting membrane potential (mV) -61.5 ± 7.6 (3) -61.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5b resting membrane potential (mV) -64.8 ± 8.7 (5) -64.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex corticothalamic pyramidal neurons layer 6 with fast AHP resting membrane potential (mV) -68.4 ± 3.7 (5) -68.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex non-corticothalamic pyramidal neurons layer 6 with medium AHP resting membrane potential (mV) -66.2 ± 7.0 (5) -66.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex pyramidal neurons layer 2/3 membrane time constant (ms) 11.5 ± 2.6 (5) 11.5 (ms) Data Table
Neocortex layer 4 stellate cell barrel cortex layer 4 neurons membrane time constant (ms) 7.5 ± 4.5 (5) 7.5 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5a membrane time constant (ms) 11.5 ± 4.6 (3) 11.5 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5b membrane time constant (ms) 11.7 ± 5.1 (5) 11.7 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex corticothalamic pyramidal neurons layer 6 with fast AHP membrane time constant (ms) 9.8 ± 3.0 (5) 9.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex non-corticothalamic pyramidal neurons layer 6 with medium AHP membrane time constant (ms) 7.9 ± 2.6 (5) 7.9 (ms) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex pyramidal neurons layer 2/3 input resistance (MΩ) 51.1 ± 27.5 (5) 51.1 (MΩ) Data Table
Neocortex layer 4 stellate cell barrel cortex layer 4 neurons input resistance (MΩ) 68.3 ± 28.8 (5) 68.3 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5a input resistance (MΩ) 65.3 ± 34.4 (3) 65.3 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5b input resistance (MΩ) 48.7 ± 29.5 (5) 48.7 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex corticothalamic pyramidal neurons layer 6 with fast AHP input resistance (MΩ) 62.2 ± 18.1 (5) 62.2 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex non-corticothalamic pyramidal neurons layer 6 with medium AHP input resistance (MΩ) 48.1 ± 11.8 (5) 48.1 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex pyramidal neurons layer 2/3 spike threshold -47.6 ± 7.9 (5) -47.6 (mV) Data Table
Neocortex layer 4 stellate cell barrel cortex layer 4 neurons spike threshold -41.3 ± 15.6 (5) -41.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5a spike threshold -40.2 ± 7.2 (3) -40.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5b spike threshold -50.6 ± 10.5 (5) -50.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex corticothalamic pyramidal neurons layer 6 with fast AHP spike threshold -41.4 ± 5.1 (5) -41.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex non-corticothalamic pyramidal neurons layer 6 with medium AHP spike threshold -43.1 ± 7.1 (5) -43.1 (mV) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex pyramidal neurons layer 2/3 spike amplitude from resting (mV) 96.2 ± 8.0 (5) 96.2 (mV) Data Table
Neocortex layer 4 stellate cell barrel cortex layer 4 neurons spike amplitude from resting (mV) 103.8 ± 10.2 (5) 103.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5a spike amplitude from resting (mV) 85.9 ± 10.0 (3) 85.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5b spike amplitude from resting (mV) 97.9 ± 5.7 (5) 97.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex corticothalamic pyramidal neurons layer 6 with fast AHP spike amplitude from resting (mV) 89.4 ± 6.4 (5) 89.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex non-corticothalamic pyramidal neurons layer 6 with medium AHP spike amplitude from resting (mV) 94.0 ± 16.8 (5) 94.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex pyramidal neurons layer 2/3 spike half-width (ms) 0.85 ± 0.24 (5) 0.85 (ms) Data Table
Neocortex layer 4 stellate cell barrel cortex layer 4 neurons spike half-width (ms) 0.86 ± 0.39 (5) 0.86 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5a spike half-width (ms) 0.88 ± 0.18 (3) 0.88 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5b spike half-width (ms) 0.72 ± 0.29 (5) 0.72 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex corticothalamic pyramidal neurons layer 6 with fast AHP spike half-width (ms) 0.77 ± 0.16 (5) 0.77 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex non-corticothalamic pyramidal neurons layer 6 with medium AHP spike half-width (ms) 0.71 ± 0.13 (5) 0.71 (ms) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex pyramidal neurons layer 2/3 fast AHP amplitude (mV) 2.7 ± 2.8 (5) 2.7 (mV) Data Table
Neocortex layer 4 stellate cell barrel cortex layer 4 neurons fast AHP amplitude (mV) -1.5 ± 2.0 (5) 1.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5a fast AHP amplitude (mV) -3.9 ± 3.0 (3) 3.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5b fast AHP amplitude (mV) 4.9 ± 2.6 (5) 4.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex corticothalamic pyramidal neurons layer 6 with fast AHP fast AHP amplitude (mV) -6.1 ± 3.3 (5) 6.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex non-corticothalamic pyramidal neurons layer 6 with medium AHP fast AHP amplitude (mV) -1.1 ± 3.0 (5) 1.1 (mV) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex pyramidal neurons layer 2/3 slow AHP amplitude (mV) -1.2 ± 1.3 (5) 1.2 (mV) Data Table
Neocortex layer 4 stellate cell barrel cortex layer 4 neurons slow AHP amplitude (mV) -1.6 ± 1.0 (5) 1.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5a slow AHP amplitude (mV) -4.9 ± 0.7 (3) 4.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex pyramidal neurons layer 5b slow AHP amplitude (mV) -2.5 ± 4.4 (5) 2.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex corticothalamic pyramidal neurons layer 6 with fast AHP slow AHP amplitude (mV) -2.4 ± 3.3 (5) 2.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex non-corticothalamic pyramidal neurons layer 6 with medium AHP slow AHP amplitude (mV) -3.3 ± 1.9 (5) 3.3 (mV) Data Table