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Article: Reduction of an afterhyperpolarization current increases excitability in striatal cholinergic interneurons in rat parkinsonism.

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Sanchez G; Rodriguez MJ; Pomata P; Rela L; Murer MG
J. Neurosci., 2011


Table 1.

IsAHP contributes to the mAHP in striatal cholinergic interneurons

Control rats 6-OHDA rats Control rats + barium 6-OHDA rats + barium
First action potential in spike train
    Threshold (mV) −41.1 ± 1.6 −44.2 ± 1.9 −42.8 ± 1.4 −46.5 ± 1.8
    Max rising phase slope (mV/ms) 218.0 ± 13.8 260.8 ± 18.5 220.9 ± 9.0 230.6 ± 11.9
    Amplitude (mV)a 79.4 ± 3.0 87.2 ± 3.1 87.8 ± 2.0 94.0 ± 2.2
    Width at half amplitude (ms)b 0.45 ± 0.01 0.50 ± 0.02 0.61 ± 0.02 0.67 ± 0.02
    mAHP amplitude (mV)c 17.9 ± 1.4 12.8 ± 1.5 2.95 ± 0.6 7.40 ± 1.1
Last control action potential and time-matched action potential in 6-OHDA rats
    Threshold (mV) −48.1 ± 0.8 −48.6 ± 1.1 −45.1 ± 1.6 −48.8 ± 1.3
    Max rising phase slope (mV/ms)d 207.3 ± 11.8 197.5 ± 13.6 146.0 ± 14.8 166.5 ± 12.2
    Amplitude (mV) 87.0 ± 1.9 91.9 ± 2.1 80.0 ± 3.8 89.1 ± 3.6
    Width at half amplitude (ms)e 1.10 ± 0.08 1.18 ± 0.07 2.31 ± 0.39 1.98 ± 0.24
    mAHP amplitude (mV)f 10.3 ± 0.6 6.5 ± 0.6 5.7 ± 0.5 4.9 ± 0.4

  • Parameters are from spike trains evoked with 1 s, 230 pA current pulses. Data are mean ± SEM of n = 10 control interneurons and n = 16 interneurons from 6-OHDA rats. Amplitudes were measured from threshold. Statistical testing was performed with a two-way ANOVA with before and after barium being considered as a repeated measure.

  • ↵aSignificant lesion (p = 0.01) and barium effects (p = 0.0064) without interaction.

  • ↵bSignificant barium effect (p < 0.0001) without lesion effect and interaction.

  • ↵cSignificant barium effect (p < 0.0001) and interaction (p = 0.0003), NS lesion effect (p = 0.8). Bonferroni post hoc comparisons show more significant effects of barium in control (p < 0.001) than 6-OHDA rats (p < 0.05).

  • ↵dSignificant barium effect (p = 0.0002) without lesion effect and interaction. The increased excitability under barium may compromise recovery of the action current. Note that barium has no effect on the first spike rising phase slope.

  • ↵eSignificant barium effect (p < 0.0001) without lesion effect and interaction.

  • ↵fSignificant barium effect (p < 0.0001), lesion effect (p = 0.0052), and interaction (p = 0.0001). Bonferroni post hoc comparisons show a significant difference between groups before barium (p < 0.001), which becomes NS under barium (p > 0.05). Moreover, barium had a more significant effect in controls (p < 0.001) than 6-OHDA rats (p < 0.05).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum cholinergic cell Dorsolateral striatum cholinergic motor interneuron spike max rise slope (mV/ms) 218.0 ± 13.8 (63) 218.0 (mV/ms) Data Table
Neostriatum cholinergic cell Dorsolateral striatum cholinergic motor interneuron spike amplitude (mV) 79.4 ± 3.0 (63) 79.4 (mV) Data Table
Neostriatum cholinergic cell Dorsolateral striatum cholinergic motor interneuron spike half-width (ms) 0.45 ± 0.01 (63) 0.45 (ms) Data Table
Neostriatum cholinergic cell Dorsolateral striatum cholinergic motor interneuron medium AHP amplitude (mV) 17.9 ± 1.4 (63) 17.9 (mV) Data Table
Neostriatum cholinergic cell Dorsolateral striatum cholinergic motor interneuron spike threshold (mV) -41.1 ± 1.6 (63) -41.1 (mV) Data Table