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Article: The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts.

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Ovsepian SV; Friel DD
Eur. J. Neurosci., 2008


Table 1.   Na+ spike parameters in WT, tgla and WT + ω-aga-IVA PCs
 nPeak (mV)AHP (mV)HW(ms)–dV/dt(V/s)+dV/dt(V/s)CV
  1. Na+ spike amplitude and afterhyperpolarizing potential (AHP), respectively, measured from the reference voltage defined during the Na+ spike upstroke where dV/dt exceeds 5 V/s. CV, coefficient of variation of interspike intervals; –dV/dt and +dV/dt, peak magnitude of first time derivatives during upstroke and repolarization, respectively; HW, width of Na+ spike at ½ peak amplitude measured from the same reference voltage. *P < 0.05 compared with wild-type (WT).

WT1766.2 ± 3.18.2 ± 1.10.42 ± 0.04331 ± 9288 ± 12.10.09 ± 0.02
tgla1355.1 ± 2.7*3.8 ± 1.9*0.64 ± 0.04*230 ± 44*178 ± 16.3*0.18 ± 0.03*
WT + ω-Aga-IVA654.2 ± 2.3*5.1 ± 1.2*0.54 ± 0.04*254 ± 15*237 ± 11*0.17 ± 0.02*

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum Purkinje cell spike peak (mV) 66.2 ± 3.1 (17) 66.2 (mV) Data Table
Cerebellum Purkinje cell AHP amplitude (mV) 8.2 ± 1.1 (17) 8.2 (mV) Data Table
Cerebellum Purkinje cell spike half-width (ms) 0.42 ± 0.04 (17) 0.42 (ms) Data Table
Cerebellum Purkinje cell spike max decay slope (V/s) 331.0 ± 9.0 (17) 331.0 (mV/ms) Data Table
Cerebellum Purkinje cell spike max rise slope (V/s) 288.0 ± 12.1 (17) 288.0 (mV/ms) Data Table