Article: Insulin facilitates repetitive spike firing in rat insular cortex via phosphoinositide 3-kinase but not mitogen activated protein kinase cascade.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Takei H; Fujita S; Shirakawa T; Koshikawa N; Kobayashi M Neuroscience, 2010
Table 1Effects of 100 nM insulin on intrinsic electrophysiological properties of layer II/III pyramidal cells
†Resting membrane potential;††Medium-duration afterhyperpolarization;†††Slow afterhyperpolarization.⁎P<0.05(paired t-test).
Control | Insulin | |||
Mean±SEM | n | Mean±SEM | n | |
Vm† (mV) | −73.5±2.2 | 20 | −74.2±1.9 | 20 |
Input resistance (MΩ) | 28.3±1.7 | 20 | 28.7±1.6 | 20 |
Action potential | ||||
1st spike amplitude (mV) | 72.6±1.8 | 18 | 69.6±2.3 | 18 |
1st spike half duration (ms) | 1.0±0.0 | 18 | 1.0±0.0 | 18 |
10th spike amplitude (mV) | 63.8±2.0 | 18 | 62.2±2.0 | 18 |
10th spike half duration (ms) | 1.5±0.1 | 18 | 1.6±0.1 | 18 |
Rheobase (nA) | 0.55±0.06 | 19 | 0.53±0.06 | 19 |
Action potential threshold | ||||
1st threshold (mV) | −51.3±1.2 | 19 | −53.6±1.2⁎ | 19 |
2nd threshold (mV) | −47.4±1.3 | 19 | −49.4±1.4⁎ | 19 |
Last threshold (mV) | −44.3±1.9 | 16 | −46.6±1.7⁎ | 16 |
mAHP†† amplitude | ||||
1st mAHP amplitude (mV) | 3.8±0.7 | 19 | 2.4±1.0 | 19 |
2nd mAHP amplitude (mV) | 8.0±0.7 | 19 | 6.8±0.7 | 19 |
Last mAHP amplitude (mV) | 14.2±1.0 | 19 | 12.9±1.1 | 19 |
Spike interval | ||||
1st inter-spike interval (ms) | 17.0±4.3 | 19 | 14.8±3.3 | 19 |
2nd inter-spike interval (ms) | 33.8±7.2 | 19 | 29.1±6.2⁎ | 19 |
Last inter-spike interval (ms) | 99.6±13.2 | 18 | 67.7±6.7⁎ | 18 |
Frequency at 1 nA (Hz) | 13.8±1.8 | 18 | 18.1±2.7⁎ | 18 |
f/I slope (Hz/nA) | 23.7±2.3 | 19 | 29.5±3.2⁎ | 19 |
sAHP††† amplitude (mV) | 3.5±0.6 | 19 | 4.0±0.7 | 19 |