AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Free Fatty Acid Effects on the Atrial Myocardium: Membrane Ionic Currents Are Remodeled by the Disruption of T-Tubular Architecture.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
O'Connell RP; Musa H; Gomez MS; Avula UM; Herron TJ; Kalifa J; Anumonwo JM
PLoS ONE, 2015


10.1371/journal.pone.0133052.t001 Electrophysiological properties of atrial myocytes incubated in palmitic (PA), stearic (SA), oleic (OA) acids and vehicle control (CTL).
RMP (mV) AP Amplitude (mV) AP Overshoot (mV) dv/dtmax (mV/msec) Cell Cap (pF)
CTL n = 9; N = 3 -78.7 ± 0.90 106.5 ± 3.63 28.0 ± 3.44 227.9 ± 12.6 59.2 ± 2.94
PA n = 12; N = 3 -79.5 ± 0.81 118.8 ± 4.20 36.3 ± 3.26 231.8 ± 19.4 63.7 ± 5.15
CTL n = 22; N = 5 -79.2 ± 0.6 126.6 ± 2.52 34.0 ± 2.04 223.9 ± 13.1 63.1 ± 3.08
SA n = 24; N = 5 -80.3 ± 0.7 119.0 ± 2.92 34.3 ± 2.54 210.0 ± 13.8 53.8 ± 2.55*
CTL n = 6; N = 2 -77.8 ± 0.74 119.0 ± 2.68 37.3 ± 1.92 192.5 ± 18.3 71.1 ± 5.98
OA n = 5; N = 2CTL n = 6; N = 2 -79.5 ± 1.21-77.8 ± 0.74 123.2 ± 4.02119.0 ± 2.68 38.0 ± 2.9237.3 ± 1.92 199.7 ± 12.0192.5 ± 18.3 64.9 ± 2.7971.1 ± 5.98
OA n = 5; N = 2 -79.5 ± 1.21 123.2 ± 4.02 38.0 ± 2.92 199.7 ± 12.0 64.9 ± 2.79

Acquisition of Resting Membrane Potential (RMP), Action Potential (AP) Amplitude, Action Potential Overshoot, dv/dtmax, and Cell Capacitance by patch clamp is presented with animal matched controls (CTL). (*p<0.05).


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other left atrial appendage myocyte resting membrane potential (mV) -79.2 ± 0.6 (22) -- Data Table
Other left atrial appendage myocyte spike amplitude (mV) 126.6 ± 2.52 (22) -- Data Table
Other left atrial appendage myocyte spike peak (mV) 34.0 ± 2.04 (22) -- Data Table
Other left atrial appendage myocyte spike max rise slope (mV/msec) 223.9 ± 13.1 (22) -- Data Table
Other left atrial appendage myocyte cell capacitance (pF) 63.1 ± 3.08 (22) -- Data Table
Other left atrial appendage myocyte resting membrane potential (mV) -78.7 ± 0.9 (9) -- Data Table
Other left atrial appendage myocyte resting membrane potential (mV) -77.8 ± 0.74 (6) -- Data Table
Other left atrial appendage myocyte spike amplitude (mV) 119.0 ± 2.68 (6) -- Data Table
Other left atrial appendage myocyte spike peak (mV) 37.3 ± 1.92 (6) -- Data Table
Other left atrial appendage myocyte spike max rise slope (mV/msec) 192.5 ± 18.3 (6) -- Data Table
Other left atrial appendage myocyte spike amplitude (mV) 106.5 ± 3.63 (9) -- Data Table
Other left atrial appendage myocyte cell capacitance (pF) 71.1 ± 5.98 (6) -- Data Table
Other left atrial appendage myocyte spike peak (mV) 28.0 ± 3.44 (9) -- Data Table
Other left atrial appendage myocyte spike max rise slope (mV/msec) 227.9 ± 12.6 (9) -- Data Table
Other left atrial appendage myocyte cell capacitance (pF) 59.2 ± 2.94 (9) -- Data Table