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Article: Intrinsic electrophysiology of mouse corticospinal neurons: a class-specific triad of spike-related properties.

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Suter BA; Migliore M; Shepherd GM
Cereb. Cortex, 2013


Table 1

Intrinsic properties of motor cortex corticospinal neurons at 1 month compared with corticostriatal neurons at the same age, and corticospinal neurons recorded at a later age, with a different internal solution, or in a separate cortical area

Parameter Corticospinal, 1 month Corticostriatal, 1 month Corticospinal, 4 months Corticospinal, no EGTA Corticospinal, Region B
N 23 10 10 9 7
Resting membrane potential (mV) -82.7 ± 2.5 -84.3 ± 3.8 -85.4 ± 3.2* -81.6 ± 4.4 -83.6 ± 3.9
Input resistance (MΩ) 42.7 ± 13.2 90.6 ± 13.4** 35.7 ± 7.6 39.2 ± 12.6 47.1 ± 11.1
Sag (%) 21.0 ± 6.6 6.7 ± 4.8** 20.0 ± 3.6 19.0 ± 6.0 18.5 ± 4.6
AP width (ms) 0.65 ± 0.13 1.04 ± 0.25** 0.51 ± 0.03** 0.59 ± 0.06 0.61 ± 0.03
Maximum dV/dt (mV/ms) 400 ± 91 250 ± 68** 498 ± 55** 492 ± 95* 488 ± 45*
Minimum dV/dt (mV/ms) -134 ± 33 -66 ± 19** -175 ± 10** -153 ± 23 -147 ± 15
AP threshold (mV) -52.3 ± 3.0 -45.6 ± 3.0** -55.8 ± 3.0* -55.4 ± 4.8 -53.7 ± 3.0
AP peak (mV) 23.6 ± 6.5 20.1 ± 5.3** 25.9 ± 3.5 30.2 ± 3.7* 32.2 ± 3.3**
AP amplitude (mV) 75.8 ± 7.9 65.6 ± 6.0** 81.7 ± 3.2* 85.6 ± 6.9** 85.7 ± 4.8**
% change in AP width 0.15 ± 2.9 7.65 ± 5.0** 3.1 ± 3.8* 3.7 ± 4.6* 4.4 ± 5.9*
Estimated rheobase (pA) 341 ± 86 182 ± 73** 361 ± 87 330 ± 76 286 ± 57
f-I slope (Hz/nA) 98 ± 18 61 ± 21** 115 ± 29* 86 ± 24 110 ± 23
f-I linearity index 0.77 ± 0.14 0.61 ± 0.10** 0.75 ± 0.18 0.82 ± 0.26 0.80 ± 0.17
SFA ratio 0.87 ± 0.24 1.70 ± 0.25** 0.88 ± 0.20 1.03 ± 0.34 0.77 ± 0.11

  • Values represent the sample mean ± SD. The % change in AP width is based on comparison of the first to eighth APs at 10 Hz. The f-I linearity index is defined below (Fig. 8H). Spike frequency adaptation (SFA) ratio: Average of the last 2 ISIs divided by the average of the first 2 ISIs. Reported P-values are by t-test, except for AP threshold, where Wilcoxon rank-sum test was used. P-values are based on comparison of each data set with the 1-month corticospinal data set.

  • *P < 0.05, **P < 0.005.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron resting membrane potential (mV) -85.4 ± 3.2 (10) -85.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron resting membrane potential (mV) -81.6 ± 4.4 (9) -81.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron resting membrane potential (mV) -83.6 ± 3.9 (7) -83.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron input resistance (MΩ) 42.7 ± 13.2 (23) 42.7 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron input resistance (MΩ) 90.6 ± 13.4 (10) 90.6 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron input resistance (MΩ) 35.7 ± 7.6 (10) 35.7 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron input resistance (MΩ) 39.2 ± 12.6 (9) 39.2 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron input resistance (MΩ) 47.1 ± 11.1 (7) 47.1 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron sag ratio 21.0 ± 6.6 (23) 0.21 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron sag ratio 6.7 ± 4.8 (10) 0.067 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron sag ratio 20.0 ± 3.6 (10) 0.2 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron sag ratio 19.0 ± 6.0 (9) 0.19 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron sag ratio 18.5 ± 4.6 (7) 0.185 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike half-width (ms) 0.65 ± 0.13 (23) 0.65 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron spike half-width (ms) 1.04 ± 0.25 (10) 1.04 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike half-width (ms) 0.51 ± 0.03 (10) 0.51 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike half-width (ms) 0.59 ± 0.06 (9) 0.59 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike half-width (ms) 0.61 ± 0.03 (7) 0.61 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike max rise slope (mV/ms) 400.0 ± 91.0 (23) 400.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron spike max rise slope (mV/ms) 250.0 ± 68.0 (10) 250.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike max rise slope (mV/ms) 498.0 ± 55.0 (10) 498.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike max rise slope (mV/ms) 492.0 ± 95.0 (9) 492.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike max rise slope (mV/ms) 488.0 ± 45.0 (7) 488.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike max decay slope (mV/ms) -134.0 ± 33.0 (23) 134.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron spike max decay slope (mV/ms) -66.0 ± 19.0 (10) 66.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike max decay slope (mV/ms) -175.0 ± 10.0 (10) 175.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike max decay slope (mV/ms) -153.0 ± 23.0 (9) 153.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike max decay slope (mV/ms) -147.0 ± 15.0 (7) 147.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike threshold (mV) -52.3 ± 3.0 (23) -52.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron spike threshold (mV) -45.6 ± 3.0 (10) -45.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike threshold (mV) -55.8 ± 3.0 (10) -55.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike threshold (mV) -55.4 ± 4.8 (9) -55.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike threshold (mV) -53.7 ± 3.0 (7) -53.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike peak (mV) 23.6 ± 6.5 (23) 23.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron spike peak (mV) 20.1 ± 5.3 (10) 20.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike peak (mV) 25.9 ± 3.5 (10) 25.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike peak (mV) 30.2 ± 3.7 (9) 30.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike peak (mV) 32.2 ± 3.3 (7) 32.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike amplitude (mV) 75.8 ± 7.9 (23) 75.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron spike amplitude (mV) 65.6 ± 6.0 (10) 65.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike amplitude (mV) 81.7 ± 3.2 (10) 81.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike amplitude (mV) 85.6 ± 6.9 (9) 85.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron spike amplitude (mV) 85.7 ± 4.8 (7) 85.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron rheobase (pA) 341.0 ± 86.0 (23) 341.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron rheobase (pA) 182.0 ± 73.0 (10) 182.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron rheobase (pA) 361.0 ± 87.0 (10) 361.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron rheobase (pA) 330.0 ± 76.0 (9) 330.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron rheobase (pA) 286.0 ± 57.0 (7) 286.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron FI slope (Hz/nA) 98.0 ± 18.0 (23) 98.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron FI slope (Hz/nA) 61.0 ± 21.0 (10) 61.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron FI slope (Hz/nA) 115.0 ± 29.0 (10) 115.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron FI slope (Hz/nA) 86.0 ± 24.0 (9) 86.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron FI slope (Hz/nA) 110.0 ± 23.0 (7) 110.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron resting membrane potential (mV) -82.7 ± 2.5 (23) -82.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron adaptation ratio (last/first ISI) 0.87 ± 0.24 (23) 0.87 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron adaptation ratio (last/first ISI) 1.7 ± 0.25 (10) 1.7 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron adaptation ratio (last/first ISI) 0.88 ± 0.2 (10) 0.88 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticospinal thick-tufted large pyramidal neuron adaptation ratio (last/first ISI) 1.03 ± 0.34 (9) 1.03 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5b corticostriatal pyramidal neuron resting membrane potential (mV) -84.3 ± 3.8 (10) -84.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Secondary somatosensory cortex layer 5b corticospinal thick-tufted large pyramidal neuron adaptation ratio (last/first ISI) 0.77 ± 0.11 (7) 0.77 (ratio) Data Table