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Article: Morphological and physiological characterization of pyramidal neuron subtypes in rat medial prefrontal cortex.

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van Aerde KI; Feldmeyer D
Cereb. Cortex, 2015


Table 3

Electrophysiological properties of pyramidal neurons in layer 2-6 (L2-L6) of the rat prefrontal cortex

Layer 2 3 5 5/6 6
Subclass L2 L3 RS L3 broad Ad L3 bursting L3 slender Ad L5 slender LR L5 slender HR L5 RS L5 wide L6 tall L6 small L6 short
n 10 7 4 7 3 30 11 18 4 4 2 4
ISI-1/ISI-9 0.22 ± 0.03 0.19 ± 0.04 0.11 ± 0.01 0.09 ± 0.02 0.11 ± 0.02 0.21 ± 0.02 0.27 ± 0.03 0.22 ± 0.02 0.31 ± 0.11 0.46 ± 0.07 1.06 ± 0.42** 0.42 ± 0.12
ISI-2/ISI-9 0.52 ± 0.05 0.46 ± 0.09 0.28 ± 0.03 0.15 ± 0.03 0.21 ± 0.04 0.43 ± 0.03 0.50 ± 0.04 0.79 ± 0.04 0.46 ± 0.14 0.75 ± 0.11 1.28 ± 0.39** 0.66 ± 0.19
ISI-3/ISI-9 0.75 ± 0.05 0.71 ± 0.09 0.53 ± 0.04 0.23 ± 0.05**,a 0.33 ± 0.06 0.61 ± 0.03 0.67 ± 0.05 0.91 ± 0.02 0.64 ± 0.12 0.86 ± 0.10 1.35 ± 0.20**,b 1.12 ± 0.14
Increase firing rate (Hz/100 pA) 6.2 ± 0.5 6.2 ± 0.7 8.0 ± 1.0 1.3 ± 0.2 5.7 ± 0.4 5.6 ± 0.3 7.0 ± 0.7 6.4 ± 0.2 10.2 ± 2.6 15.6 ± 1.5*/** 20.8 ± 5.2** 11.6 ± 1.8
RMP (mV) -76.0 ± 1.3 -79.2 ± 0.8 -71.5 ± 1.9 -66.5 ± 0.9 -66.3 ± 0.6 -67.4 ± 0.5 -65.4 ± 0.9 -64.0 ± 0.7 -66.4 ± 2.0 -68.1 ± 1.9 -76.1 ± 1.3 -75.2 ± 2.9
Voltage sag (%) 3.0 ± 0.8 0.3 ± 0.3 3.0 ± 1.4 11.0 ± 1.5 15.3 ± 4.0 14.1 ± 1.4 14.0 ± 2.1 23.8 ± 1.7*/** 10.6 ± 3.3 10.3 ± 2.5 6.9 ± 1.4 4.4 ± 2.5
Input resistance (MΩ) 175 ± 21 143 ± 9 185 ± 9 138 ± 11 172 ± 31 144 ± 6 249 ± 22 90 ± 5 365 ± 49** 276 ± 47 433 ± 40** 236 ± 18
Time constant (ms) 20.1 ± 1.2 18.4 ± 0.5 27.1 ± 2.7 29.1 ± 2.0 31.9 ± 7.9 31.7 ± 1.3 41.7 ± 2.3 21.2 ± 1.0 33.6 ± 2.9 29.7 ± 4.0 21.8 ± 5.5 21.4 ± 4.7
Rheobase (pA) 181 ± 12*/** 244 ± 11*/** 115 ± 16 120 ± 10 93 ± 23 123 ± 7 67 ± 4 179 ± 10*/** 53 ± 6 78 ± 22 65 ± 5 125 ± 23

  • Note: aL3 bursting neurons are different from all other subtypes with the exception of L3 slender tufted adapting neurons (P = 0.41).

  • bL6 small neurons are different from all other subtypes with the exception of L6 short neurons (P = 0.12).

  • For clarity, the results of the post hoc comparison of groups is only given (values in bold followed with asterisks) when a cell type is different from all other cell types, unless otherwise specified. *P < 0.05, **P < 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 2 pyramidal cell adaptation ratio 0.22 ± 0.03 (10) 0.22 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted regular spiking pyramidal cell adaptation ratio 0.19 ± 0.04 (7) 0.19 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted adapting pyramidal cell adaptation ratio 0.11 ± 0.01 (4) 0.11 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted burst spiking pyramidal cell adaptation ratio 0.09 ± 0.02 (7) 0.09 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted adapting pyramidal cell adaptation ratio 0.11 ± 0.02 (3) 0.11 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted low input resistance adapting pyramidal cell adaptation ratio 0.21 ± 0.02 (30) 0.21 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted high input resistance adapting pyramidal cell adaptation ratio 0.27 ± 0.03 (11) 0.27 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 broad tufted regular spiking pyramidal cell adaptation ratio 0.22 ± 0.02 (18) 0.22 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layers 5-6 wide apical dendrite pyramidal cell adaptation ratio 0.31 ± 0.11 (4) 0.31 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 tall apical dendrite pyramidal cell receiving input from neocortex pyramidal cell layer 1 adaptation ratio 0.46 ± 0.07 (4) 0.46 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 small apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 adaptation ratio 1.06 ± 0.42 (2) 1.06 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 short apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 adaptation ratio 0.42 ± 0.12 (4) 0.42 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 2 pyramidal cell resting membrane potential (mV) -76.0 ± 1.3 (10) -76.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted regular spiking pyramidal cell resting membrane potential (mV) -79.2 ± 0.8 (7) -79.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted adapting pyramidal cell resting membrane potential (mV) -71.5 ± 1.9 (4) -71.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted burst spiking pyramidal cell resting membrane potential (mV) -66.5 ± 0.9 (7) -66.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted adapting pyramidal cell resting membrane potential (mV) -66.3 ± 0.6 (3) -66.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted low input resistance adapting pyramidal cell resting membrane potential (mV) -67.4 ± 0.5 (30) -67.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted high input resistance adapting pyramidal cell resting membrane potential (mV) -65.4 ± 0.9 (11) -65.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 broad tufted regular spiking pyramidal cell resting membrane potential (mV) -64.0 ± 0.7 (18) -64.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layers 5-6 wide apical dendrite pyramidal cell resting membrane potential (mV) -66.4 ± 2.0 (4) -66.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 tall apical dendrite pyramidal cell receiving input from neocortex pyramidal cell layer 1 resting membrane potential (mV) -68.1 ± 1.9 (4) -68.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 small apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 resting membrane potential (mV) -76.1 ± 1.3 (2) -76.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 short apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 resting membrane potential (mV) -75.2 ± 2.9 (4) -75.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 2 pyramidal cell sag ratio 3.0 ± 0.8 (10) 0.03 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted regular spiking pyramidal cell sag ratio 0.3 ± 0.3 (7) 0.003 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted adapting pyramidal cell sag ratio 3.0 ± 1.4 (4) 0.03 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted burst spiking pyramidal cell sag ratio 11.0 ± 1.5 (7) 0.11 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted adapting pyramidal cell sag ratio 15.3 ± 4.0 (3) 0.153 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted low input resistance adapting pyramidal cell sag ratio 14.1 ± 1.4 (30) 0.141 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted high input resistance adapting pyramidal cell sag ratio 14.0 ± 2.1 (11) 0.14 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 broad tufted regular spiking pyramidal cell sag ratio 23.8 ± 1.7 (18) 0.238 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layers 5-6 wide apical dendrite pyramidal cell sag ratio 10.6 ± 3.3 (4) 0.106 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 tall apical dendrite pyramidal cell receiving input from neocortex pyramidal cell layer 1 sag ratio 10.3 ± 2.5 (4) 0.103 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 small apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 sag ratio 6.9 ± 1.4 (2) 0.069 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 short apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 sag ratio 4.4 ± 2.5 (4) 0.044 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 2 pyramidal cell input resistance (MΩ) 175.0 ± 21.0 (10) 175.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted regular spiking pyramidal cell input resistance (MΩ) 143.0 ± 9.0 (7) 143.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted adapting pyramidal cell input resistance (MΩ) 185.0 ± 9.0 (4) 185.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted burst spiking pyramidal cell input resistance (MΩ) 138.0 ± 11.0 (7) 138.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted adapting pyramidal cell input resistance (MΩ) 172.0 ± 31.0 (3) 172.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted low input resistance adapting pyramidal cell input resistance (MΩ) 144.0 ± 6.0 (30) 144.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted high input resistance adapting pyramidal cell input resistance (MΩ) 249.0 ± 22.0 (11) 249.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 broad tufted regular spiking pyramidal cell input resistance (MΩ) 90.0 ± 5.0 (18) 90.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layers 5-6 wide apical dendrite pyramidal cell input resistance (MΩ) 365.0 ± 49.0 (4) 365.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 tall apical dendrite pyramidal cell receiving input from neocortex pyramidal cell layer 1 input resistance (MΩ) 276.0 ± 47.0 (4) 276.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 small apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 input resistance (MΩ) 433.0 ± 40.0 (2) 433.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 short apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 input resistance (MΩ) 236.0 ± 18.0 (4) 236.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 2 pyramidal cell membrane time constant (ms) 20.1 ± 1.2 (10) 20.1 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted regular spiking pyramidal cell membrane time constant (ms) 18.4 ± 0.5 (7) 18.4 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted adapting pyramidal cell membrane time constant (ms) 27.1 ± 2.7 (4) 27.1 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted burst spiking pyramidal cell membrane time constant (ms) 29.1 ± 2.0 (7) 29.1 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted adapting pyramidal cell membrane time constant (ms) 31.9 ± 7.9 (3) 31.9 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted low input resistance adapting pyramidal cell membrane time constant (ms) 31.7 ± 1.3 (30) 31.7 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted high input resistance adapting pyramidal cell membrane time constant (ms) 41.7 ± 2.3 (11) 41.7 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 broad tufted regular spiking pyramidal cell membrane time constant (ms) 21.2 ± 1.0 (18) 21.2 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layers 5-6 wide apical dendrite pyramidal cell membrane time constant (ms) 33.6 ± 2.9 (4) 33.6 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 tall apical dendrite pyramidal cell receiving input from neocortex pyramidal cell layer 1 membrane time constant (ms) 29.7 ± 4.0 (4) 29.7 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 small apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 membrane time constant (ms) 21.8 ± 5.5 (2) 21.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 short apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 membrane time constant (ms) 21.4 ± 4.7 (4) 21.4 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 2 pyramidal cell rheobase (pA) 181.0 ± 12.0 (10) 181.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted regular spiking pyramidal cell rheobase (pA) 244.0 ± 11.0 (7) 244.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 broad tufted adapting pyramidal cell rheobase (pA) 115.0 ± 16.0 (4) 115.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted burst spiking pyramidal cell rheobase (pA) 120.0 ± 10.0 (7) 120.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Medial Prefrontal Cortex layer 3 slender tufted adapting pyramidal cell rheobase (pA) 93.0 ± 23.0 (3) 93.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted low input resistance adapting pyramidal cell rheobase (pA) 123.0 ± 7.0 (30) 123.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 slender tufted high input resistance adapting pyramidal cell rheobase (pA) 67.0 ± 4.0 (11) 67.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 5 broad tufted regular spiking pyramidal cell rheobase (pA) 179.0 ± 10.0 (18) 179.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layers 5-6 wide apical dendrite pyramidal cell rheobase (pA) 53.0 ± 6.0 (4) 53.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 tall apical dendrite pyramidal cell receiving input from neocortex pyramidal cell layer 1 rheobase (pA) 78.0 ± 22.0 (4) 78.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 small apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 rheobase (pA) 65.0 ± 5.0 (2) 65.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex layer 6 short apical dendrite pyramidal cell receiving input from Neocortex pyramidal cell layers 3-6 rheobase (pA) 125.0 ± 23.0 (4) 125.0 (pA) Data Table