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Article: CGRP inhibits neurons of the bed nucleus of the stria terminalis: implications for the regulation of fear and anxiety.

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Gungor NZ; Pare D
J. Neurosci., 2014


Table 1.

Effect of CGRP (1 μm) on the electroresponsive properties of BNST-AL neuronsa

Control CGRP p n
Resting potential (mV) -61.5 ± 1.5 -60.9 ± 1.4 0.27 26
Input resistance (mΩ) 715.7 ± 74.1 731.2 ± 74.6 0.38 26
Time constant (ms) 46.9 ± 4.6 50.6 ± 4.0 0.25 26
Rheobase (pA) 40.8 ± 6.1 42.5 ± 5.7 0.44 12
Spike threshold (mV) -48.1 ± 2.2 -49.4 ± 2.3 0.31 12
Spike latency (ms) 98.2 ± 13.3 104.3 ± 15.9 0.7 12
Spike amplitude (mV) 87.8 ± 3 83.6 ± 3.63 0.16 12
Spike duration at half amplitude (ms) 0.48 ± 0.03 0.49 ± 0.01 0.8 12
Firing rate at rheobase (Hz) 0.75 ± 0.21 0.75 ± 0.14 1 12

  • ↵aValues are mean ± SEM. We restricted our analysis of passive properties and spike characteristics to cells tested in the same conditions (before and after CGRP), with no other drugs present. Also, 8 additional cells tested with 250 nm CGRP were not included because this dose had no effect. Finally, for the spike characteristics, in 14 of the 26 cells meeting our selection criteria, no responses to positive current pulses were recorded.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
BNST (ALG) Bed nucleus of the stria terminalus anterolateral sector cell membrane time constant (ms) 46.9 ± 4.6 (26) 46.9 (ms) Data Table
BNST (ALG) Bed nucleus of the stria terminalus anterolateral sector cell rheobase (pA) 40.8 ± 6.1 (26) 40.8 (pA) Data Table
BNST (ALG) Bed nucleus of the stria terminalus anterolateral sector cell resting membrane potential (mV) -61.5 ± 1.5 (26) -61.5 (mV) Data Table
BNST (ALG) Bed nucleus of the stria terminalus anterolateral sector cell spike threshold (mV) -48.1 ± 2.2 (26) -48.1 (mV) Data Table
BNST (ALG) Bed nucleus of the stria terminalus anterolateral sector cell first spike latency (ms) 98.2 ± 13.3 (26) 98.2 (ms) Data Table
BNST (ALG) Bed nucleus of the stria terminalus anterolateral sector cell spike amplitude (mV) 87.8 ± 3.0 (26) 87.8 (mV) Data Table
BNST (ALG) Bed nucleus of the stria terminalus anterolateral sector cell spike half-width (ms) 0.48 ± 0.03 (26) 0.48 (ms) Data Table
BNST (ALG) Bed nucleus of the stria terminalus anterolateral sector cell firing frequency (Hz) 0.75 ± 0.21 (26) 0.75 (Hz) Data Table
BNST (ALG) Bed nucleus of the stria terminalus anterolateral sector cell input resistance (mΩ) 715.7 ± 74.1 (26) 715.7 (MΩ) Data Table