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Article: Dopamine D2 receptors regulate collateral inhibition between striatal medium spiny neurons.

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Lalchandani RR; van der Goes MS; Partridge JG; Vicini S
J. Neurosci., 2013


Table 1.

Membrane properties of mature D1 and D2 MSNs in primary culturesa

Nontreated Treated
D1 MSN D2 MSN D1 MSN D2 MSN
Resting membrane potential (mV) -73.9 ± 1.8 (n = 22) -75.5 ± 1.5 (n = 43) -75.1 ± 5.2 (n = 9) -73.9 ± 1.4 (n = 38)
Input resistance (mΩ) 265 ± 18 (n = 19) 215 ± 23 (n = 42) 268 ± 27 (n = 18) 209 ± 20 (n = 42)
Capacitance (pF) 54 ± 5 (n = 16) 43 ± 4 (n = 23) 52 ± 4 (n = 13) 67 ± 5 (n = 19)***,+
Inward rectification index 1.7 ± 0.1 (n = 8) 1.7 ± 0.1 (n = 22) 2.0 ± 0.2 (n = 8) 2.1 ± 0.1 (n = 13)

  • ↵aWhole-cell recordings from identified MSNs in nontreated and treated conditions showed that chronic D2R activation increased the capacitance and inward rectification index in only D2 MSNs. D1 MSNs remained unchanged despite the treatment, serving as an internal control (data derived from at least 4 culture preparations).

  • ↵***p < 0.001, comparing same cell type between treatment conditions using an unpaired t test;

  • ↵+p < 0.05 comparing different cell types within a treatment condition using an unpaired t test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum medium spiny neuron Striatal dopaminergic D1 medium spiny neuron cell capacitance (pF) 54.0 ± 5.0 (16) 54.0 (pF) Data Table
Neostriatum medium spiny neuron Striatal dopaminergic D2 medium spiny neuron cell capacitance (pF) 43.0 ± 4.0 (23) 43.0 (pF) Data Table
Neostriatum medium spiny neuron Striatal dopaminergic D1 medium spiny neuron resting membrane potential (mV) -73.9 ± 1.8 (22) -73.9 (mV) Data Table
Neostriatum medium spiny neuron Striatal dopaminergic D2 medium spiny neuron resting membrane potential (mV) -75.5 ± 1.5 (43) -75.5 (mV) Data Table
Neostriatum medium spiny neuron Striatal dopaminergic D1 medium spiny neuron input resistance (mΩ) 265.0 ± 18.0 (19) 265.0 (MΩ) Data Table
Neostriatum medium spiny neuron Striatal dopaminergic D2 medium spiny neuron input resistance (mΩ) 215.0 ± 23.0 (42) 215.0 (MΩ) Data Table