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Article: Contributions of diverse excitatory and inhibitory neurons to recurrent network activity in cerebral cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Neske GT; Patrick SL; Connors BW
J. Neurosci., 2015


Table 2.

Properties of excitatory and inhibitory neurons in barrel cortexa

L5 Pyr (RS) (n = 44) L5 Pyr (IB) (n = 3) L2/3 Pyr (n = 88) L5 PV (n = 43) L2/3 PV (n = 34) L5 SOM (n = 45) L2/3 SOM (n = 50) L2/3 VIP (n = 37) L2/3 NPY (n = 23)
RMP (mV) -63.5 (3.2) -59.0 (1.7) -67.4 (4.3) -67.1 (3.2) -66.4 (3.0) -63.2 (4.0) -59.9 (4.0) -65.7 (1.9) -66.4 (3.6)
Rin (MΩ) 48.0 (25.9) 27.1 (13.3) 45.7 (19.6) 49.4 (33.0) 33.0 (7.6) 79.7 (41.0) 95.7 (53.0) 126.0 (54.7) 89.8 (31.2)
AP thresh (mV) -44.8 (5.3) -50.5 (0.5) -41.5 (6.0) -42.3 (5.0) -41.6 (3.4) -48.1 (8.0) -41.8 (6.3) -43.7 (5.3) -38.7 (5.6)
τm (ms) 11.8 (4.8) 16.6 (6.6) 10.5 (5.1) 4.0 (1.8) 3.1 (1.3) 11.7 (7.5) 11.8 (4.6) 10.9 (3.8) 10.0 (8.8)
AP half-width (ms) 0.66 (1.1) 0.58 (0.5) 0.84 (0.3) 0.25 (0.05) 0.22 (0.04) 0.40 (0.05) 0.44 (0.1) 0.45 (0.1) 0.66 (0.4)
Up firing rate (Hz) 4.9 (4.2) 15.8 (2.9) 1.7 (2.6) 30.6 (1.4) 26.5 (19.5) 9.7 (9.0) 8.0 (13.1) 5.9 (8.6) 1.6 (2.0)
Up depolarization (mV) 4.4 (1.6) 2.6 (1.7) 6.8 (2.6) 8.5 (3.2) 8.3 (2.5) 3.9 (2.7) 3.2 (1.7) 5.1 (2.4) 6.2 (0.8)
σUp/σDown 10.7 (5.3) 13.7 (8.8) 11.7 (7.7) 10.4 (4.1) 17.5 (4.7) 6.4 (4.9) 5.9 (4.0) 6.4 (2.9) 6.5 (2.1)
GE (nS) 1.5 (2.0) NA* 2.8 (1.6) 2.7 (1.9) 4.9 (2.8) 2.1 (1.8) 1.5 (1.26) 1.0 (0.4) 0.9 (0.5)
Gi (nS) 3.4 (1.6) NA* 4.7 (3.1) 1.0 (1.4) 1.3 (0.8) 1.1 (1.4) 1.0 (0.8) 1.2 (0.7) 1.8 (1.6)

  • ↵aValues are mean (SD). RMP, Resting membrane potential; Rin, input resistance; AP thresh, action potential threshold; τm, membrane time constant; AP half-width, action potential half-width; σUp/σDown, normalized membrane potential SD during Up state; GE, excitatory conductance; GI, inhibitory conductance. n refers to the total number of cells studied in current clamp and voltage clamp.

  • ↵*NA, Not applicable; RS cells could not be distinguished from IB cells using Cs-gluconate internal solution.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 regular spiking pyramidal cells resting membrane potential (mV) -63.5 (44) -63.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 intrinsically bursting pyramidal cells resting membrane potential (mV) -59.0 (3) -59.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 resting membrane potential (mV) -67.4 (88) -67.4 (mV) Data Table
Neocortex basket cell barrel cortex layer 5 parvalbumin expressing interneuron resting membrane potential (mV) -67.1 (43) -67.1 (mV) Data Table
Neocortex basket cell barrel cortex layer 2/3 parvalbumin expressing interneuron resting membrane potential (mV) -66.4 (34) -66.4 (mV) Data Table
Neocortex Martinotti cell barrel cortex layer 5 somatostatin expressing interneuron resting membrane potential (mV) -63.2 (45) -63.2 (mV) Data Table
Neocortex Martinotti cell barrel cortex layer 2/3 somatostatin expressing interneuron resting membrane potential (mV) -59.9 (50) -59.9 (mV) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 vasoactive intestinal peptide expressing interneuron resting membrane potential (mV) -65.7 (37) -65.7 (mV) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 neuropeptide Y expressing interneuron resting membrane potential (mV) -66.4 (23) -66.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 regular spiking pyramidal cells input resistance (MΩ) 48.0 (44) 48.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 intrinsically bursting pyramidal cells input resistance (MΩ) 27.1 (3) 27.1 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 input resistance (MΩ) 45.7 (88) 45.7 (MΩ) Data Table
Neocortex basket cell barrel cortex layer 5 parvalbumin expressing interneuron input resistance (MΩ) 49.4 (43) 49.4 (MΩ) Data Table
Neocortex basket cell barrel cortex layer 2/3 parvalbumin expressing interneuron input resistance (MΩ) 33.0 (34) 33.0 (MΩ) Data Table
Neocortex Martinotti cell barrel cortex layer 5 somatostatin expressing interneuron input resistance (MΩ) 79.7 (45) 79.7 (MΩ) Data Table
Neocortex Martinotti cell barrel cortex layer 2/3 somatostatin expressing interneuron input resistance (MΩ) 95.7 (50) 95.7 (MΩ) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 vasoactive intestinal peptide expressing interneuron input resistance (MΩ) 126.0 (37) 126.0 (MΩ) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 neuropeptide Y expressing interneuron input resistance (MΩ) 89.8 (23) 89.8 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 regular spiking pyramidal cells spike threshold (mV) -44.8 (44) -44.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 intrinsically bursting pyramidal cells spike threshold (mV) -50.5 (3) -50.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 spike threshold (mV) -41.5 (88) -41.5 (mV) Data Table
Neocortex basket cell barrel cortex layer 5 parvalbumin expressing interneuron spike threshold (mV) -42.3 (43) -42.3 (mV) Data Table
Neocortex basket cell barrel cortex layer 2/3 parvalbumin expressing interneuron spike threshold (mV) -41.6 (34) -41.6 (mV) Data Table
Neocortex Martinotti cell barrel cortex layer 5 somatostatin expressing interneuron spike threshold (mV) -48.1 (45) -48.1 (mV) Data Table
Neocortex Martinotti cell barrel cortex layer 2/3 somatostatin expressing interneuron spike threshold (mV) -41.8 (50) -41.8 (mV) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 vasoactive intestinal peptide expressing interneuron spike threshold (mV) -43.7 (37) -43.7 (mV) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 neuropeptide Y expressing interneuron spike threshold (mV) -38.7 (23) -38.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 regular spiking pyramidal cells membrane time constant (ms) 11.8 (44) 11.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 intrinsically bursting pyramidal cells membrane time constant (ms) 16.6 (3) 16.6 (ms) Data Table
Neocortex pyramidal cell layer 2-3 membrane time constant (ms) 10.5 (88) 10.5 (ms) Data Table
Neocortex basket cell barrel cortex layer 5 parvalbumin expressing interneuron membrane time constant (ms) 4.0 (43) 4.0 (ms) Data Table
Neocortex basket cell barrel cortex layer 2/3 parvalbumin expressing interneuron membrane time constant (ms) 3.1 (34) 3.1 (ms) Data Table
Neocortex Martinotti cell barrel cortex layer 5 somatostatin expressing interneuron membrane time constant (ms) 11.7 (45) 11.7 (ms) Data Table
Neocortex Martinotti cell barrel cortex layer 2/3 somatostatin expressing interneuron membrane time constant (ms) 11.8 (50) 11.8 (ms) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 vasoactive intestinal peptide expressing interneuron membrane time constant (ms) 10.9 (37) 10.9 (ms) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 neuropeptide Y expressing interneuron membrane time constant (ms) 10.0 (23) 10.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 regular spiking pyramidal cells spike half-width (ms) 0.66 (44) 0.66 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 5 intrinsically bursting pyramidal cells spike half-width (ms) 0.58 (3) 0.58 (ms) Data Table
Neocortex pyramidal cell layer 2-3 spike half-width (ms) 0.84 (88) 0.84 (ms) Data Table
Neocortex basket cell barrel cortex layer 5 parvalbumin expressing interneuron spike half-width (ms) 0.25 (43) 0.25 (ms) Data Table
Neocortex basket cell barrel cortex layer 2/3 parvalbumin expressing interneuron spike half-width (ms) 0.22 (34) 0.22 (ms) Data Table
Neocortex Martinotti cell barrel cortex layer 5 somatostatin expressing interneuron spike half-width (ms) 0.4 (45) 0.4 (ms) Data Table
Neocortex Martinotti cell barrel cortex layer 2/3 somatostatin expressing interneuron spike half-width (ms) 0.44 (50) 0.44 (ms) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 vasoactive intestinal peptide expressing interneuron spike half-width (ms) 0.45 (37) 0.45 (ms) Data Table
Neocortex interneuron deep barrel cortex layer 2/3 neuropeptide Y expressing interneuron spike half-width (ms) 0.66 (23) 0.66 (ms) Data Table