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Article: Hippocampal function is compromised in an animal model of multiple sclerosis.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Novkovic T; Shchyglo O; Gold R; Manahan-Vaughan D Neuroscience, 2015
| Membrane property | Early phase | Late phase | ||||||
|---|---|---|---|---|---|---|---|---|
| OVA | OVA + PTX | MOG + PTX | ANOVA F = p = | OVA | OVA + PTX | MOG + PTX | ANOVA F = p = | |
| Resting membrane potential, mV | -65.75 ± 1.1 | -66.66 ± 0.9 | -66.36 ± 0.9 | F(2,26) = 0.149 p = 0.9 | -64.67 ± 1.0 | -64.27 ± 0.9 | -65.05 ± 0.8 | F(2,27) = 0.18 p = 0.8 |
| Input resistance, MΩ | 140.9 ± 6.5 | 152.4 ± 8.7 | 144.8 ± 6.2 | F(2,26) = 0.54 p = 0.6 | 145.5 ± 10.4 | 124.3 ± 10.6 | 134.7 ± 12.7 | F(2,27) = 0.7 p = 0.5 |
| Membrane time constant, ms | 9.9 ± 0.8 | 11.02 ± 1.3 | 9.4 ± 1.0 | F(2,26) = 0.52 p = 0.6 | 9.6 ± 1.4 | 10.7 ± 0.6 | 10.1 ± 0.7 | F(2,27) = 0.33 p = 0.72 |
| Amplitude of action potential, mV | 104.8 ± 1.1 | 104.5 ± 0.9 | 103.4 ± 1.9 | F(2,26) = 0.23 p = 0.8 | 103.5 ± 0.7 | 103.4 ± 0.9 | 102.6 ± 1.6 | F(2,27) = 0.08 p = 0.9 |
| Current threshold, pA | 111.2 ± 7.4 | 113.5 ± 9.9 | 104.1 ± 5.8 | F(2,26) = 0.37 p = 0.7 | 108.9 ± 8.6 | 120 ± 7.4 | 124 ± 11.3 | F(2,27) = 0.6 p = 0.5 |
| Adaptation ratio | 1.88 ± 0.35 | 1.85 ± 0.3 | 1.97 ± 0.27 | F(2,26) = 0.04 p = 0.9 | 2.00 ± 0.18 | 1.69 ± 0.16 | 2.12 ± 0.25 | F(2,27) = 1.2 p = 0.3 |
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | input resistance (MΩ) | 140.9 ± 6.5 | 140.9 (MΩ) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | input resistance (MΩ) | 145.5 ± 10.4 | 145.5 (MΩ) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | resting membrane potential (mV) | -65.75 ± 1.1 | -65.75 (mV) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | membrane time constant (ms) | 9.9 ± 0.8 | 9.9 (ms) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | membrane time constant (ms) | 9.6 ± 1.4 | 9.6 (ms) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | spike amplitude (mV) | 104.8 ± 1.1 | 104.8 (mV) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | spike amplitude (mV) | 103.5 ± 0.7 | 103.5 (mV) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | rheobase (pA) | 111.2 ± 7.4 | 111.2 (pA) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | rheobase (pA) | 108.9 ± 8.6 | 108.9 (pA) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | adaptation ratio (last/first ISI) | 1.88 ± 0.35 | 1.88 (ratio) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | adaptation ratio (last/first ISI) | 2.0 ± 0.18 | 2.0 (ratio) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 stratum radiatum pyramidal immunized with ovalbumin neurons | resting membrane potential (mV) | -64.67 ± 1.0 | -64.67 (mV) | Data Table |