AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
McLeod F; Ganley R; Williams L; Selfridge J; Bird A; Cobb SR
Neuroscience, 2013


Intrinsic propertyWild type (MeCP2+v)Mecp2+/stop
MeCP2+veMeCP2-ve% Change
Resting membrane potential (mV)-61.7 ± 1.6-60.2 ± 1.4-62.2 ± 1.92-2%
Membrane time constant (ms)31.4 ± 2.626.7 ± 1.925.2 ± 3.2+6%
Input resistance (MΩ)125.8 ± 11.0143.8 ± 15.1159.1 ± 13.7+11%
Threshold (mV)-37.7 ± 0.7-37.7 ± 1.8-39.4 ± 1.7+5%
Amplitude (mV)84.2 ± 2.883.6 ± 1.886.4 ± 2.0+3%
20-80% rise time (ms)0.08 ± 0.010.08 ± 0.0040.09 ± 0.01+12%
½ Height duration (ms)1.04 ± 0.061.05 ± 0.021.15 ± 0.06+10%
Maximal rise rate (mV ms-1)582 ± 41583 ± 27546 ± 41-6%
Maximal decay rate (mV ms-1)106 ± 7101 ± 394 ± 5-7%
Medium AHP amplitude (mV)11.1 ± 4.39.4 ± 0.810.2 ± 0.9-8%

Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell input resistance (MΩ) 125.8 ± 11.0 (14) 125.8 (MΩ) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -37.7 ± 0.7 (14) -37.7 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -61.7 ± 1.6 (14) -61.7 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 84.2 ± 2.8 (14) 84.2 (mV) Data Table
Hippocampus CA1 pyramidal cell spike rise time (ms) 0.08 ± 0.01 (14) 0.08 (ms) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.04 ± 0.06 (14) 1.04 (ms) Data Table
Hippocampus CA1 pyramidal cell spike max rise slope 582.0 ± 41.0 (14) 582.0 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell spike max decay slope 106.0 ± 7.0 (14) 106.0 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell medium AHP amplitude (mV) 11.1 ± 4.3 (14) 11.1 (mV) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (ms) 31.4 ± 2.6 (14) 31.4 (ms) Data Table