Article: Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) McLeod F; Ganley R; Williams L; Selfridge J; Bird A; Cobb SR Neuroscience, 2013
Intrinsic property | Wild type (MeCP2+v) | Mecp2+/stop | ||
---|---|---|---|---|
MeCP2+ve | MeCP2-ve | % Change | ||
Resting membrane potential (mV) | -61.7 ± 1.6 | -60.2 ± 1.4 | -62.2 ± 1.92 | -2% |
Membrane time constant (ms) | 31.4 ± 2.6 | 26.7 ± 1.9 | 25.2 ± 3.2 | +6% |
Input resistance (MΩ) | 125.8 ± 11.0 | 143.8 ± 15.1 | 159.1 ± 13.7 | +11% |
Threshold (mV) | -37.7 ± 0.7 | -37.7 ± 1.8 | -39.4 ± 1.7 | +5% |
Amplitude (mV) | 84.2 ± 2.8 | 83.6 ± 1.8 | 86.4 ± 2.0 | +3% |
20-80% rise time (ms) | 0.08 ± 0.01 | 0.08 ± 0.004 | 0.09 ± 0.01 | +12% |
½ Height duration (ms) | 1.04 ± 0.06 | 1.05 ± 0.02 | 1.15 ± 0.06 | +10% |
Maximal rise rate (mV ms-1) | 582 ± 41 | 583 ± 27 | 546 ± 41 | -6% |
Maximal decay rate (mV ms-1) | 106 ± 7 | 101 ± 3 | 94 ± 5 | -7% |
Medium AHP amplitude (mV) | 11.1 ± 4.3 | 9.4 ± 0.8 | 10.2 ± 0.9 | -8% |