Article: Enhanced long-term potentiation in the hippocampus of rats expressing mutant presenillin-1 is age related.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Pybus R; Barnard E; Estibeiro P; Mullins J; MacLeod N Neurobiol. Dis., 2003
Wild type (mean ± SEM) | Transgenic (mean ± SEM) | Significancea | |
---|---|---|---|
Passive properties | |||
Resting membrane potential (RMP) (mV) | -66.49 ± 1.23 (34) | -63.39 ± 0.61 (48) | P = 0.513 M-W |
Membrane resistance (Rm) (MΩ) | 36.59 ± 2.25 (36) | 39.31 ± 1.96 (52) | P = 0.369 t-test |
Time constant (ms) | 30.62 ± 2.41 (28) | 27.81 ± 1.79 (41) | P = 0.343 t-test |
Action potential properties | |||
Firing threshold (mV) | -49.980 ± 1.382 (32) | -49.790 ± 0.636 (52) | P = 0.754 t-test |
Amplitude (mV) | 71.78 ± 0.99 (31) | 71.34 ± 0.83 (52) | P = 0.724 M-W |
Rise time (ms) | 0.589 ± 0.013 (31) | 0.594 ± 0.012 (52) | P = 0.877 M-W |
Fall time (ms) | 1.078 ± 0.023 (31) | 1.068 ± 0.024 (52) | P = 0.778 t-test |
Half width (ms) | 0.851 ± 0.010 (31) | 0.869 ± 0.011 (52) | P = 0.264 t-test |
After depolarising potential (ADP) amplitude (mV) | 4.507 ± 0.838 (18) | 4.058 ± 0.612 (22) | P = 0.661 t-test |
After hyperpolarising potential (fAHP) amplitude (mV) | 1.530 ± 0.350 (21) | 1.271 ± 0.267 (34) | P = 0.562 M-W |
1/2 max excitatory post-synaptic potential (EPSP) properties | |||
Amplitude (mV) | 5.704 ± 0.512 (22) | 5.995 ± 0.369 (30) | P = 0.638 t-test |
Rise time (ms) | 5.645 ± 0.488 (22) | 6.029 ± 0.335 (30) | P = 0.251 M-W |
Fall time (ms) | 19.659 ± 4.901 (22) | 30.697 ± 4.502 (30) | P = 0.060 M-W |
Half width (ms)a | 10.718 ± 1.964 (22) | 14.847 ± 1.497 (30) | P = 0.016 M-W* |
mAHP amplitude (mV) | |||
8 action potential (APs) | 4.082 ± 0.282 (36) | 3.830 ± 0.228(46) | P = 0.485 t-test |
12 APs | 5.173 ± 0.336 (32) | 4.557 ± 0.249(44) | P = 0.137 t-test |
16 APs | 5.297 ± 0.349 (30) | 4.794 ± 0.319(40) | P = 0.295 t-test |
20 APs | 5.170 ± 0.369 (25) | 5.039 ± 0.311(38) | P = 0.788 t-test |
sAHP amplitude (mV) | |||
8 APs | 3.471 ± 0.268 (36) | 3.178 ± 0.224 (46) | P = 0.402 t-test |
12 APs | 4.230 ± 0.325 (30) | 3.603 ± 0.231 (40) | P = 0.110 t-test |
16 APs | 4.158 ± 0.320 (32) | 3.679 ± 0.292 (44) | P = 0.276 t-test |
20 APs | 4.214 ± 0.375 (25) | 3.829 ± 0.290 (38) | P = 0.152 t-test |
sAHP duration (ms) | |||
8 APs | 3.375 ± 0.067 (36) | 3.472 ± 0.048 (46) | P = 0.233 t-test |
12 APs | 3.447 ± 0.046 (30) | 3.513 ± 0.040 (40) | P = 0.154 M-W |
16 APs | 3.424 ± 0.061 (32) | 3.426 ± 0.041 (44) | P = 0.749 t-test |
20 APs | 3.378 ± 0.046 (25) | 3.329 ± 0.041 (38) | P = 0.731 t-test |