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Article: Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.

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Nenov MN; Tempia F; Denner L; Dineley KT; Laezza F
J. Neurophysiol., 2015


Table 5.

Comparison of active and passive properties of type II DG granule cells under different experimental conditions

Wild-type (n = 8)Tg2576 (n = 13)Tg2576 + RSG (n = 11)P
First peak latency, ms265.3 ± 17.4303.2 ± 26.8296.5 ± 360.7
Itrh, pA41.3 ± 5.536.9 ± 4.341.8 ± 2.90.6
Vtrh, mV-45.2 ± 2.7-43.9 ± 1.9-43 ± 1.90.8
MRP, mV-69.2 ± 0.9-72.9 ± 1.5-67.1 ± 2.30.06
Rin, MΩ297.2 ± 13.6345.7 ± 14.9342.2 ± 22.40.16
τ, ms31.9 ± 1.831.5 ± 230.7 ± 1.90.9
Cm, pF108.7 ± 989.1 ± 7.188.5 ± 6.30.16
  • Tg2576 and RSG-treated Tg2576 were compared with wild-type. Data are mean ± SE. P values were obtained with 1-way ANOVA and post hoc Dunnett test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dentate gyrus granule cell Dentate gyrus type 2 mature granule cell first spike latency (ms) 265.3 ± 17.4 265.3 (ms) Data Table
Dentate gyrus granule cell Dentate gyrus type 2 mature granule cell rheobase (pA) 41.3 ± 5.5 41.3 (pA) Data Table
Dentate gyrus granule cell Dentate gyrus type 2 mature granule cell spike threshold (mV) -45.2 ± 2.7 -45.2 (mV) Data Table
Dentate gyrus granule cell Dentate gyrus type 2 mature granule cell resting membrane potential (mV) -69.2 ± 0.9 -69.2 (mV) Data Table
Dentate gyrus granule cell Dentate gyrus type 2 mature granule cell input resistance (MΩ) 297.2 ± 13.6 297.2 (MΩ) Data Table
Dentate gyrus granule cell Dentate gyrus type 2 mature granule cell membrane time constant (ms) 31.9 ± 1.8 31.9 (ms) Data Table
Dentate gyrus granule cell Dentate gyrus type 2 mature granule cell cell capacitance (pF) 108.7 ± 9.0 108.7 (pF) Data Table