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Article: Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex.

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Frick A; Feldmeyer D; Sakmann B
J. Physiol. (Lond.), 2007


Table 1. Developmental changes in properties of synaptic connections and input resistance

Age P14–16 P17–20 P24–29
Asterisks indicate statistically significant difference from the P14–16 age group (*P < 0.05, **P < 0.005).
Unitary EPSP (mV) 1.11 ± 1.01 (n = 29) 1.24 ± 1.28 (n = 27) 0.65 ± 0.77 (n = 24)*
Coefficient of variation 0.38 ± 0.20 (n = 29) 0.30 ± 0.16 (n = 26)  0.54 ± 0.20 (n = 24)**
Failure rate (%) 2.39 ± 4.08 (n = 29) 1.44 ± 3.29 (n = 22) 10.61 ± 8.68 (n = 22)**
PPR (%) (EPSP2/EPSP1 × 100) 70.1 ± 16.6 (n = 16)  82.6 ± 10.8 (n = 17)* 103.8 ± 32.5 (n = 21)**
PPR (%) (EPSP3/EPSP1 × 100) 60.2 ± 15.7 (n = 16) 66.9 ± 10.9 (n = 17)  98.3 ± 29.8 (n = 21)**
20–80% Rise time (ms) 1.84 ± 0.48 (n = 19)  1.35 ± 0.54 (n = 23)* 1.61 ± 0.36 (n = 11) 
Decay time constant (ms) 25.9 ± 6.9 (n = 19)   17.8 ± 4.5 (n = 18)** 20.4 ± 7.4 (n = 12)* 
Latency (ms) 1.24 ± 0.44 (n = 16) 1.07 ± 0.40 (n = 20) 1.15 ± 0.45 (n = 9)  
Input resistance (MΩ) 144 ± 57 (n = 37)     90 ± 30 (n = 33)**  83 ± 28 (n = 28)**

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Layer 5a somatosensory barrel cortex pyramidal neurons input resistance (MΩ) 144.0 ± 57.0 (37) 144.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5a somatosensory barrel cortex pyramidal neurons input resistance (MΩ) 90.0 ± 30.0 (33) 90.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5a somatosensory barrel cortex pyramidal neurons input resistance (MΩ) 83.0 ± 28.0 (28) 83.0 (MΩ) Data Table