AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Hourez R; Servais L; Orduz D; Gall D; Millard I; de Kerchove d'Exaerde A; Cheron G; Orr HT; Pandolfo M; Schiffmann SN
J. Neurosci., 2011

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum Purkinje cell access resistance 23.65 (18) 23.65 (MΩ) Data Table
Cerebellum Purkinje cell AHP voltage -68.18 (18) -68.18 (mV) Data Table
Cerebellum Purkinje cell cell capacitance 334.14 (18) 334.14 (pF) Data Table
Cerebellum Purkinje cell FI slope 0.23 (18) 0.23 (Hz/nA) Data Table
Cerebellum Purkinje cell input resistance (GΩ) 0.14 (18) 140.0 (MΩ) Data Table
Cerebellum Purkinje cell resting membrane potential -58.55 (18) -58.55 (mV) Data Table
Cerebellum Purkinje cell spike half-width 0.23 (18) 0.23 (ms) Data Table
Cerebellum Purkinje cell spike max decay slope -277.09 (18) 277.09 (mV/ms) Data Table
Cerebellum Purkinje cell spike max rise slope 368.52 (18) 368.52 (mV/ms) Data Table

Report miscurated data

Metadata values

Experimental condition Value
Species Mice
PrepType in vitro
Strain Mouse, Transgenic
AnimalAge 14.0 - 21.0
RecTemp 20.0 - 25.0
ExternalSolution 5.0
InternalSolution 5.0
internal_1_Mg 4.0
internal_1_Ca 0.05
internal_1_Na 4.0
internal_1_Cl 4.1
internal_1_K 126.0
JxnPotential Unreported
ElectrodeType Perforated patch
internal_0_pH 7.2
internal_0_Na 10.0
internal_0_K 160.0
internal_0_HEPES 5.0
internal_0_Cl 10.0
internal_0_glucose 15.0
external_0_pH 7.4
external_0_Mg 1.19
external_0_Na 147.18
external_0_K 2.0
external_0_Cl 126.0
external_0_Ca 2.0
external_0_glucose 11.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
1575 Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1. Hourez R; Servais L; Orduz D; Gall D; Millard I; de Kerchove d'Exaerde A; Cheron G; Orr HT; Pandolfo M; Schiffmann SN J. Neurosci. 2011 False 9 Kerrie Tsigounis, Shreejoy Tripathy, Ellie Hogan, Nathalie Binnion, 5
1576 Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1. Hourez R; Servais L; Orduz D; Gall D; Millard I; de Kerchove d'Exaerde A; Cheron G; Orr HT; Pandolfo M; Schiffmann SN J. Neurosci. 2011 False 1 0