Article: Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Hourez R; Servais L; Orduz D; Gall D; Millard I; de Kerchove d'Exaerde A; Cheron G; Orr HT; Pandolfo M; Schiffmann SN J. Neurosci., 2011
Unit | WT (no. of cells = 18) | SCA1 (no. of cells = 38) | t test | ||||
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Mean | SEM | Mean | SEM | ||||
Passive parameters | |||||||
Access resistance | MΩ | 23.65 | 1.11 | 22.86 | 2.85 | 0.89 | NS |
Apparent membrane capacitance | pF | 334.14 | 25.17 | 349.32 | 18.74 | 0.63 | NS |
Membrane input resistance | GΩ | 0.14 | 0.02 | 0.16 | 0.02 | 0.56 | NS |
Resting membrane potential | mV | −58.55 | 1.36 | −57.39 | 1.00 | 0.51 | NS |
Action potential analysis (injected current = 0 pA) | |||||||
Afterhyperpolarization | mV | −63.38 | 1.09 | −61.54 | 0.95 | 0.25 | NS |
Frequency | Hz | 42.27 | 3.22 | 29.11 | 2.06 | 0.00 | ** |
Half-width | ms | 0.27 | 0.01 | 0.25 | 0.01 | 0.17 | NS |
Ascending slope | V/s | 314.31 | 32.70 | 361.00 | 17.02 | 0.17 | NS |
Descending slope | V/s | −226.84 | 27.57 | −235.53 | 12.79 | 0.74 | NS |
Action potential analysis (excitability recordings) | |||||||
Afterhyperpolarization | mV | −68.18 | 1.53 | −65.40 | 0.95 | 0.13 | NS |
Half-width | ms | 0.23 | 0.01 | 0.22 | 0.01 | 0.49 | NS |
Ascending slope | V/s | 368.52 | 26.60 | 420.36 | 16.06 | 0.10 | NS |
Descending slope | V/s | −277.09 | 25.77 | −293.49 | 14.98 | 0.56 | NS |
Excitability slope | Hz/pA | 0.23 | 0.02 | 0.21 | 0.01 | 0.13 | NS |
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Passive parameters and action potential analysis from patch-clamp recordings of Purkinje cells from 2- to 3-week-old WT and SCA1 mice.
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↵NS, No significant difference (p > 0.05); **p < 0.01.