Table 1.
Comparison of electrophysiological properties in adult +/+ and stg/stg in deep layer cortical neurons
| +/+ | stg/stg | P | |
|---|---|---|---|
| V r, mV | −74.4 ± 1.5 (25) | −73.7 ± 1.7 (27) | ns |
| R in, MΩ | 170 ± 25 (20) | 170 ± 13 (22) | ns |
| Time constant, ms | 26.9 ± 2.6 (14) | 32.1 ± 3.1 (22) | ns |
| AP overshoot, mV | 37.0 ± 3.7 | 34.1 ± 3.14 [11–58] (23) | ns |
| [12–67] (14) | |||
| 0-Mg2+ induced afterburst hyperpolarization, mV | 6.9 ± 1.1 (14) | 1.5 ± 0.7 (12) | <0.0001 |
| [↓78%] | |||
| AP 10–90% rise time, ms | 0.34 ± 0.01 (14) | 0.28 ± 0.01 (23) | <0.04 |
| [↓15%] | |||
| AP 10–90% decay time, ms | 0.59 ± 0.01 (14) | 0.51 ± 0.01 (23) | <0.01 |
| [↓13.5%] | |||
| AP half-width, ms | 0.81 ± 0.03 (14) | 0.71 ± 0.01 (23) | <0.01 |
| [↓12.3%] | |||
| Rheobase current, pA | 80 ± 17 (10) | 25 ± 8 (11) | <0.03 |
| [↓68%] | |||
| Sag amplitude, mV, blind recordings | 1.6 ± 0.6 (5) | 8.6 ± 1.2 (5) | <0.002 |
| [↑537%] |
-
Values, except for P values, are means ± SE, with number of neurons in parentheses. Values in brackets in +/+ and stg/stg columns are ranges. +/+, wild-type mouse; stg/stg, stargazer mutant mouse; V r, resting potential; R in, input resistance; AP, action potential; ns, not significant.