Article: Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Planert H; Berger TK; Silberberg G PLoS ONE, 2013
D1 MSNs (n = 32) | D2 MSNs (n = 30) | ||||||
n | mean | SD | n | mean | SD | p-value | |
Rest potential when impaling cell (mV) | 24 | -78.65 | 4.75 | 25 | -78.91 | 3.93 | 0.834 |
Baseline current (pA) | 30 | -4.13 | 47.17 | 29 | -6.25 | 73.16 | 0.895 |
Baseline membrane potential for recordings (mV) | 32 | -78.97 | 2.15 | 29 | -79.70 | 2.97 | 0.266 |
Amplitude of first AP (mV) | 29 | 78.50 | 7.73 | 29 | 78.77 | 9.42 | 0.907 |
Duration of first AP (ms) | 29 | 1.83 | 0.42 | 29 | 1.75 | 0.49 | 0.523 |
Width of first AP (ms) | 29 | 0.77 | 0.10 | 29 | 0.75 | 0.11 | 0.352 |
Amplitude of second AP (mV) | 29 | 62.16 | 8.29 | 29 | 64.34 | 10.04 | 0.371 |
Duration of second AP (ms) | 29 | 1.94 | 0.35 | 29 | 1.92 | 0.33 | 0.803 |
Width of second AP (ms) | 29 | 1.00 | 0.18 | 29 | 0.97 | 0.15 | 0.472 |
Amplitude change first to second AP (%) | 29 | -20.75 | 7.90 | 29 | -18.18 | 8.81 | 0.247 |
AP duration change (%) | 29 | 7.34 | 11.70 | 29 | 12.40 | 14.55 | 0.150 |
AP width change (%) | 29 | 29.42 | 13.55 | 29 | 30.28 | 9.80 | 0.782 |
Input resistance at rest (MΩ) | 30 | 85.26 | 48.77 | 27 | 96.44 | 48.97 | 0.392 |
Input resistance [depolarized] (MΩ ) | 31 | 131.70 | 57.79 | 28 | 151.37 | 71.51 | 0.248 |
Input resistance [hyperpolarized] (MΩ ) | 31 | 50.67 | 29.46 | 28 | 59.90 | 28.87 | 0.230 |
Membrane time constant at rest (ms) | 29 | 5.16 | 2.39 | 28 | 5.98 | 3.00 | 0.254 |
Membrane time constant [depolarized] (ms) | 32 | 11.05 | 3.15 | 29 | 12.43 | 4.37 | 0.159 |
Membrane time constant [hyperpolarized] (ms) | 31 | 1.84 | 1.08 | 29 | 2.54 | 2.11 | 0.114 |
Membrane time constant for delta pulse (ms) | 30 | 4.84 | 2.43 | 29 | 5.87 | 3.38 | 0.186 |
Threshold for APs (mV) | 32 | -42.73 | 2.65 | 28 | -44.29 | 4.44 | 0.112 |
AP drop rate (%) | 30 | -0.02 | 0.02 | 28 | -0.02 | 0.02 | 0.668 |
|
31 | 332.93 | 127.30 | 29 | 257.53 | 87.11 |
|
|
30 | 355.39 | 150.33 | 28 | 268.74 | 96.07 |
|
Slope of current/frequency relationship (Hz/pA) | 30 | 0.12 | 0.08 | 27 | 0.15 | 0.09 | 0.174 |