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Article: Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine.

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Guan D; Armstrong WE; Foehring RC
J. Neurophysiol., 2015

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons input resistance (MΩ) 139.0 ± 13.0 (35) 139.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons resting membrane potential (mV) -82.0 ± 0.8 (35) -82.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons rheobase (pA) 246.0 ± 28.0 (25) 246.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons sag ratio 6.5 ± 0.9 (28) 0.065 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons input resistance (MΩ) 138.0 ± 6.0 (102) 138.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons input resistance (MΩ) 138.0 ± 5.6 (68) 138.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons resting membrane potential (mV) -73.0 ± 0.4 (67) -73.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons resting membrane potential (mV) -75.0 ± 0.4 (102) -75.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons rheobase (pA) 97.0 ± 8.0 (62) 97.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons rheobase (pA) 172.0 ± 12.0 (76) 172.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons sag ratio 19.0 ± 1.0 (69) 0.19 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons sag ratio 25.0 ± 1.2 (37) 0.25 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike amplitude from resting (mV) 112.0 ± 2.0 (23) 112.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike half-width (ms) 1.2 ± 0.04 (23) 1.2 (ms) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike max decay slope (V/s) 89.0 ± 4.0 (23) 89.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike max rise slope (V/s) 331.0 ± 13.0 (23) 331.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike threshold (mV) -52.0 ± 1.0 (23) -52.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike amplitude from resting (mV) 100.0 ± 2.0 (71) 100.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike amplitude from resting (mV) 98.0 ± 2.0 (57) 98.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike half-width (ms) 1.0 ± 0.03 (71) 1.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike half-width (ms) 0.9 ± 0.02 (57) 0.9 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike max decay slope (V/s) 105.0 ± 3.0 (71) 105.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike max decay slope (V/s) 125.0 ± 7.0 (35) 125.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike max rise slope (V/s) 310.0 ± 10.0 (71) 310.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike max rise slope (V/s) 352.0 ± 12.0 (57) 352.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike threshold (mV) -49.0 ± 1.0 (69) -49.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike threshold (mV) -52.0 ± 1.0 (57) -52.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons medium AHP amplitude from resting (mV) 3.7 ± 0.4 (21) 3.7 (mV) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons slow AHP amplitude from resting (mV) 1.3 ± 0.2 (21) 1.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons medium AHP amplitude from resting (mV) 5.5 ± 0.2 (62) 5.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons medium AHP amplitude from resting (mV) 6.6 ± 0.3 (77) 6.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons slow AHP amplitude from resting (mV) 0.8 ± 0.2 (62) 0.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons slow AHP amplitude from resting (mV) 3.2 ± 0.2 (77) 3.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory cortex layer 2/3 pyramidal neurons adaptation percent (1 – first/last ISI) 52.0 ± 4.0 (15) 52.0 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory cortex layer 2/3 pyramidal neurons adaptation ratio (other) 24.0 ± 14.0 (15) 24.0 (None) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory cortex layer 2/3 pyramidal neurons FI slope (2 s) 55.0 ± 7.0 (15) -- Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons adaptation percent (1 – first/last ISI) 17.0 ± 2.0 (27) 17.0 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons adaptation percent (1 – first/last ISI) 76.0 ± 2.0 (21) 76.0 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons adaptation ratio (other) 39.0 ± 7.0 (21) 39.0 (None) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons adaptation ratio (other) 1.1 ± 0.3 (27) 1.1 (None) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons FI slope (2 s) 30.0 ± 1.0 (22) -- Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons FI slope (2 s) 72.0 ± 1.0 (30) -- Data Table

Report miscurated data

Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
Strain Mice, Transgenic
PrepType in vitro
AnimalAge 14.0 - 28.0
JxnPotential Corrected
InternalSolution 5.0
ExternalSolution 5.0
RecTemp 33.0 ± 1.0
JxnOffset 8.0
internal_0_Mg 2.0
internal_0_Na 7.5
internal_0_K 140.5
internal_0_GTP 0.2
internal_0_ATP 2.0
internal_0_HEPES 10.0
internal_0_Cl 21.5
external_0_pH 7.4
external_0_Mg 1.0
external_0_Na 125.0
external_0_K 3.0
external_0_Cl 3.0
external_0_Ca 2.0
external_0_glucose 20.0
external_0_picro 100.0
external_0_CPP 2.0
external_0_DNQX 6.0
external_0_DAPV 2.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
49054 Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine. Guan D; Armstrong WE; Foehring RC J. Neurophysiol. 2015 False 5 Shreejoy Tripathy, Athanasios Kritharis, 1
49053 Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine. Guan D; Armstrong WE; Foehring RC J. Neurophysiol. 2015 False 4 Shreejoy Tripathy, Athanasios Kritharis, 1
49056 Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine. Guan D; Armstrong WE; Foehring RC J. Neurophysiol. 2015 False 3 Shreejoy Tripathy, Athanasios Kritharis, 1
49058 Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine. Guan D; Armstrong WE; Foehring RC J. Neurophysiol. 2015 False 3 0
49055 Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine. Guan D; Armstrong WE; Foehring RC J. Neurophysiol. 2015 False 2 Shreejoy Tripathy, Athanasios Kritharis, 1
49057 Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine. Guan D; Armstrong WE; Foehring RC J. Neurophysiol. 2015 False 2 0